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1R0W CFTR NBD1

1)CFTR NBD1 contains an insertion of 35 residues between Beta-strands S1 and S2 colored in green.The insertion is made up of two short alpha helices which are separated by a flexible link region.

2)Altered geometry from insertion of 35 residues colored in blue for the base and ribose in NBD1 which can also be deleted and preserve its function.

3)There is also a lack of 14-27 residue between Beta-strands S4 and S6 colored in navy blue. Which in ABC transporter NBDs typically have an additional beta strand and alpha helix.


Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Lewis HA1, Buchanan SG, Burley SK, Conners K, Dickey M, Dorwart M, Fowler R, Gao X, Guggino WB, Hendrickson WA, Hunt JF, Kearins MC, Lorimer D, Maloney PC, Post KW, Rajashankar KR, Rutter ME, Sauder JM, Shriver S, Thibodeau PH, Thomas PJ, Zhang M, Zhao X, Emtage S.
EMBO J. 2004 Jan 28;23(2):282-93. Epub 2003 Dec 18.

(PubMed)

1R0W (PDB)

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